「Radiological findings of denosumab treatment for giant cell tumours of bone. (Skeletal Radiology 2020;49(9):1345-1358.)」
Giant cell tumours of bone (GCTB)のdenosumab treatmentの画像評価に関する論文です。
The development of a sclerotic neocortex and varying degrees of matrix osteosclerosis are seen on plain radiographs. Reconstitution of subarticular bone and articular surface irregularity are optimally evaluated on CT which can also quantify tumour density. MRI demonstrates heterogeneous low signal matrix and is useful to assess decrease in size of cystic and/or soft tissue components of GCTB. A fat-suppressed fluid-sensitive MR sequence is important to detect tumour reactivation. Reduction in 18F-FDG-PET avidity represents an early sensitive sign of response to denosumab treatment.
「The differentiation between aneurysmal bone cyst and telangiectatic osteosarcoma: a clinical, radiographic and MRI study. (Skeletal Radiology 2020:49(9):1375-1386.)」
Lesions with a geographic Type 1A or IB pattern of bone destruction which are completely filled with FFLs on MRI can confidently be diagnosed as ABC.
注：The Lodwick classification is a system for describing the margins of a lytic bone lesion (or lucent bone lesion). The terms used in the description suggest the level of concern for an aggressive, and possibly malignant, process.
type 1: geographic
1A: thin, sclerotic margin
1B: distinct, well-marginated border, but not sclerotic
1C: indistinct border
type 2: moth-eaten
type 3: permeative