<論文紹介:NEJM 2024;390:2108-2118.ほか>

NEJMがとても役立ちますよ、ということを以前お話ししましたが、最近のNEJM論文を紹介します。

Case 18-2024: A 64-Year-Old Woman with the Worst Headache of Her Life.(NEJM 2024;390:2108-2118.)
非常に教育的で、救急臨床の現場で役立つ症例です。雷鳴頭痛を来す病態の鑑別が学べます。

EDITORIAL: T-Cell Cancer after CAR T-Cell Therapy.(NEJM 2024;390:2120-2121.)
キメラ抗原受容体T細胞(CAR-T)療法に関して、二次性悪性腫瘍(特にT細胞性悪性腫瘍 )のリスクが問題となっているようです。

CORRESPONDENCE: Highly Pathogenic Avian Influenza A(H5N1) Virus Infection in a Dairy Farm Worker.(NEJM 2024;390:2028-2029.)
鳥インフルエンザのヒトへの感染が報告されました。

Case 12-2024: A 58-Year-Old Woman with Confusion, Aphasia, and Abnormal Head Imaging.(NEJM 2024;390:1421-1430.)
本症例も、とても教育的ですし、画像所見も興味深いです。

 

他のNEJM関連は、こちら。

(かなり数がたまったので今後はリンクははりません。ご了承ください。内容を記載しますので、ご関心があればリンク先アドレスをコピペしてご参照ください。)

(https://ocu-radiology.jp/news/news-4726/)
Anti–Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency. Kidney Injury and Hair-Straightening Products Containing Glyoxylic Acid. Myeloperoxidase antineutrophil cytoplasmic antibody–associated vasculitis. Behçet’s Syndrome.

 

(https://ocu-radiology.jp/news/news-4624/)
Coccidioidomycosis and Histoplasmosis in Immunocompetent Persons.Keratinizing desquamative squamous metaplasia due to vitamin A deficiency occurred after a bariatric operation. Syphilis Complicating Pregnancy and Congenital Syphilis.

 

(https://ocu-radiology.jp/2024/01/04/post-4597/)
Hereditary angioedema. Cronkhite–Canada syndrome.
Methemoglobinemia Outbreak in a Neonatal ICU and Maternity Ward.
Eye Infections.

(https://ocu-radiology.jp/news/news-4583/)
Chorea due to antiphospholipid syndrome and underlying systemic lupus erythematosus.
Schnitzler’s syndrome.
HNF1B-related disease consistent with renal cysts and diabetes spectrum disorder.
Liver Transplantation in a Woman with Mahvash Disease.

(https://ocu-radiology.jp/news/news-4552/)
Granulomatous lung disease as an extraintestinal manifestation of inflammatory bowel disease.
Primary pericardial mesothelioma without pleural involvement. Carcinoid heart disease due to a metastatic well-differentiated
neuroendocrine tumor (carcinoid tumor) associated with carcinoid syndrome.

(https://ocu-radiology.jp/news/news-4460/)
Noncirrhotic hyperammonemia after Roux-en-Y gastric bypass.
Periengraftment respiratory distress syndrome, a subtype of idiopathic pneumonia syndrome.
Current and Emerging Issues in Wilson’s Disease.

(https://ocu-radiology.jp/news/news-4383/)
Protein-Losing Enteropathy.
Juvenile granulosa-cell tumor.
Multiple vitamin deficiencies, including vitamin C deficiency.
Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
Histoplasmosis.
RAS-associated autoimmune leukoproliferative disorder.
Congenital absence of the main portal vein with a congenital extrahepatic portosystemic shunt (Abernethy malformation).

(https://ocu-radiology.jp/news/news-4306/)
Systemic immunoglobulin light-chain (AL) amyloidosis.
Sarcoidosis associated with tattoos.
Mansonella perstans infection.

(https://ocu-radiology.jp/news/news-4250/)
Cystic fibrosis
Functional vitamin B12 deficiency from use of nitrous oxide.
The Current and Future State of AI Interpretation of Medical
Images.

(https://ocu-radiology.jp/news/news-4177/)
Arterial calcification due to deficiency of CD73.
Systemic lupus erythematosus with membranous lupus nephritis.
A hepatic brucelloma.

(https://ocu-radiology.jp/news/news-4096/)
Paraneoplastic vasculitis of the central nervous system.
Primary biliary cholangitis with portopulmonary hypertension.
Catastrophic antiphospholipid syndrome.

(https://ocu-radiology.jp/news/news-4062/)
Hepatic adenoma, inflammatory type, with associated ischemic
necrosis and extensive hemorrhage.
Cardiac paraganglioma with a germline mutation in the gene
encoding succinate dehydrogenase subunit C (SDHC).
Primary Ovarian Insufficiency.
Cushing’s syndrome due to ectopic secretion of adrenocorticotropic
hormone from small-cell lung cancer.

(https://ocu-radiology.jp/news/news-4035/)
Adrenocortical carcinoma.
Disseminated Mycobacterium tuberculosis infection.
Whipple’s disease.
Optic nerve sheath meningioma.
Sarcoidosis.

 

(https://ocu-radiology.jp/news/news-3897/)
IgA vasculitis.
Granulomatosis with polyangiitis.
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked
(IPEX) syndrome.
Neonatal hypoglycemia due to biologically active teratoma and
the Sotos syndrome.

 

(https://ocu-radiology.jp/news/news-3897/)
Langerhans-cell histiocytosis of the lung and liver.
Chronic Candida albicans meningitis.
Bronchiectasis — A Clinical Review.
Exogenous lipoid pneumonia with a supportive history of mineral
oil ingestion.

 

(https://ocu-radiology.jp/news/news-3861/)
Takayasu’s arteritis.
Granulomatosis with polyangiitis.
Infection with Blastomyces dermatitidis.

(https://ocu-radiology.jp/news/news-3787/)
Spinal gout.
Aspiration pneumonia.
Idiopathic multicentric Castleman’ s disease (TAFRO subtype).

(https://ocu-radiology.jp/news/news-3734/)
Constrictive bronchiolitis due to military service. Cryptogenic
Organizing Pneumonia. Hereditary angioedema type I due to heterozygous deletion of exons 5 and 6 in SERPING1

(https://ocu-radiology.jp/news/news-3654/)
Multistate Outbreak of Melioidosis Associated with Imported Aromatherapy Spray.
Fever of Unknown Origin.
post–Covid-19 Hemophagocytic lymphohistiocytosis (HLH).

(https://ocu-radiology.jp/news/news-3608/)
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome.
Anti-IgLON5 IgG–associated neurologic disorder. HHV-6 encephalitis associated with CD19-directed CAR-T therapy.

(https://ocu-radiology.jp/news/news-3589/)
Fat embolism syndrome. Anti–melanoma differentiation–associated protein 5 (anti–MDA-5) dermatomyositis.
Legionella pneumonia.
Spontaneous Intracranial Hypotension.

(https://ocu-radiology.jp/news/news-3561/)
Pneumocystis jirovecii pneumonia. Seizure from neurocysticercosis.
Primary hyperparathyroidism and brown tumor.
Vascular Ehlers–Danlos syndrome.

(https://ocu-radiology.jp/news/news-3513/)
Systemic juvenile idiopathic arthritis. Challenges of Sarcoidosis and Its Management.
Chronic Meningitis. Acute human immunodeficiency virus type 1 infection.

(https://ocu-radiology.jp/news/news-3490/)
Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS) due to a biallelic expansion in RFC1.
Delayed posthypoxic leukoencephalopathy.
Vasculopathy and myocardial infarction associated with Neurofibromatosis type 1.
Nodular follicular thyroid neoplasm with a somatic NRAS mutation.

(https://ocu-radiology.jp/news/news-3354/)
Adrenal Incidentaloma. Bartonella henselae infection (cat scratch disease).
Suprasellar CNS germinoma. Extrahepatic Manifestations of Chronic HCV Infection. Leptospirosis.

(https://ocu-radiology.jp/news/news-3212/)
Lymphoplasmacytic lymphoma of the central nervous system(Bing–Neel syndrome).
Disseminated Mycobacterium bovis infection.
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. Systemic primary amyloidosis.

(https://ocu-radiology.jp/news/news-3133/)
Mycobacterium tuberculosis meningitis. Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants.
Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.
Cryptococcal meningoencephalitis and advanced human immunodeficiency virus infection.

(https://ocu-radiology.jp/news/news-3082/)
Primary hyperparathyroidism due to an ectopic parathyroid carcinoma.
Necrotizing granulomatous lymphadenitis due to Mycobacterium tuberculosis complex.
Tuberculous pericarditis.
Aceruloplasminemia, hereditary. Sensory Ganglionopathy. Borrelia miyamotoi infection. Autophagy in Human Diseas

(https://ocu-radiology.jp/news/news-3050/)
Disseminated cryptococcosis. Cryptococcus neoformans. Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.
boric acid toxicity.
Human immunodeficiency virus type 2 infection and cerebral toxoplasmosis. New-Onset Diabetes in Covid-19.

(https://ocu-radiology.jp/news/news-3023/)
Pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Lead poisoning.
Acute Ischemic Stroke. Degenerative Cervical Spondylosis.

(https://ocu-radiology.jp/news/news-2980/)
Whipple’s disease. Variant Creutzfeldt–Jakob Disease. Down Syndrome.
Phosphaturic mesenchymal tumor. LGI1 autoimmune encephalitis.

(https://ocu-radiology.jp/news/news-2903/)
Fascioliasis (Eosinophilia). Proteinase 3 antineutrophil cytoplasmic antibody–associated vasculitis consistent with granulomatosis with polyangiitis. Hantavirus cardiopulmonary syndrome. PSA Screening.

(https://ocu-radiology.jp/news/news-2788/)
Intraparenchymal and intracranial hemorrhage presumably due to birth trauma.
小児虐待. Pulmonary tumor thrombotic microangiopathy

(https://ocu-radiology.jp/news/news-2758/)
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Treatment for Spontaneous Pneumothorax. Fatal Cytomegalovirus Infection with Inherited NOS2 Deficiency.
Strongyloidiasis with human T-lymphotropic virus type 1 infection.
Disseminated coccidioidomycosis and ANCA-associated glomerulonephritis.
Photopheresis for Colitis Induced by Checkpoint-Inhibitor Therapy.
Machine Learning and the Cancer-Diagnosis Problem.
Diffuse pulmonary alveolar hemorrhage with focal infarction with vaping.

(https://ocu-radiology.jp/news/news-2601/)
Identification of Anonymous MRI Research Participants with Face-Recognition Software.
Cerebellar form of Creutzfeldt–Jakob disease.
Adenovirus meningoencephalitis. Imaging of Vaping-Associated Lung Disease.

(https://ocu-radiology.jp/news/news-2550/)
Interstitial lung disease associated with FLNA mutation. Spondyloarthritis in patients with inflammatory bowel disease (Crohn’s disease).
Inhaled GM-CSF for Pulmonary Alveolar Proteinosis.

(https://ocu-radiology.jp/news/news-2464/)
Pregnant woman with Acute suppurative appendicitis and periappendicitis.
Pheochromocytoma and Paraganglioma. Drug-Induced Liver Injury.
New Guidelines for Statistical Reporting in the Journal.

(https://ocu-radiology.jp/news/news-2436/)
Leber’s hereditary optic neuropathy. Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis.
Intestinal tuberculosis.

(https://ocu-radiology.jp/news/news-2403/)
Anaplastic carcinoma arising in association with intestinal-type mucinous carcinoma of the ovary.
(いわゆるMucinous cystic tumours with mural nodules)
West Nile virus encephalitis/West Nile virus meningoencephalitis.

(https://ocu-radiology.jp/news/news-2371)
Systemic lupus erythematosus. Contrast-Associated Acute Kidney Injury.
Mesenchymal Hamartoma of the Liver and DICER1 Syndrome.
Metastatic postpubertal immature teratoma. Machine Learning in Medicine.

(https://ocu-radiology.jp/news/news-2148/)
Idiopathic pulmonary fibrosis. Pulmonary alveolar proteinosis.
Mucinous Ovarian Carcinoma. Ocular syphilis.

(https://ocu-radiology.jp/news/news-2115/)
Herpes simplex virus lymphadenitis, Chronic lymphocytic leukemia.
Perforation of the sigmoid colon by a foreign body (toothpick) that caused a fistula to the right common iliac artery. Powassan virus encephalitis.

(https://ocu-radiology.jp/news/news-2037/)
Papulonecrotic tuberculid (cutaneous tuberculosis).
Hepatobiliary Tuberculosis. Sudden death caused by pulmonary fat embolism in a patient with miliary tuberculosis.

(https://ocu-radiology.jp/news/news-1974/)
眼窩領域Granulomatosis with polyangiitis, Susac’s syndrome.
Clostridium perfringens bacteremia with a hepatic abscess.
Osteoblastic and Osteolytic Spine Metastases by Using SWI.

(https://ocu-radiology.jp/news/news-1921/)
The t(6;11) TFEB translocation variant of renal-cell carcinoma.
比較的新しい病理組織概念でUncommonな腎腫瘤の復習.

(https://ocu-radiology.jp/news/news-1901/)
Pulmonary adenocarcinoma, hypercoagulable state with nonbacterial thrombotic endocarditis.
BK Virus–Progressive Multifocal Leukoencephalopathy.

(https://ocu-radiology.jp/news/news-1843/)
Anti–N-methyl-d-aspartate (NMDA) receptor encephalitis.
The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, associated with human herpesvirus 6. Acute Viral Encephalitis.
特にarbovirus encephalitisについて.

(https://ocu-radiology.jp/news/news-1793/)
Vitamin C deficiency (scurvy).“bachelor scurvy” Vitamin B6, folate, zinc, and selenium deficiencies.
Alcohol-use disorder. Multiple vitamin deficiencies.

(https://ocu-radiology.jp/news/news-1681/)
Polyarteritis nodosa. HBVとの関連.

(https://ocu-radiology.jp/news/news-1605/)
Membranous nephropathy, PLA2R type. IgG4との関連性など. Idiopathic Pulmonary Fibrosis.

(https://ocu-radiology.jp/news/news-1588/)
Giant-cell myocarditis. Takotsubo cardiomyopathy and catecholamine-induced crisis due to pheochromocytoma.
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.

(https://ocu-radiology.jp/news/news-1462/)
Homocystinuriaの様々な表現型:Cystathionine β-synthase deficiency, Methylenetetrahydrofolate reductase deficiency.
Primary Sjögren’s Syndrome. Antibody-Mediated Encephalitis.

(https://ocu-radiology.jp/news/news-1374/)
Immune-Related Adverse Events Associated with Immune Checkpoint Blockade.
Multiple Sclerosis. Neuromyelitis Optica Spectrum Disorders.
Adenovirus infection, disseminated.

(https://ocu-radiology.jp/news/news-1253/)
Biotin–thiamine–responsive basal ganglia disease.

(https://ocu-radiology.jp/news/news-1109/)
好酸球増多症(Eosinophilia)について.

(https://ocu-radiology.jp/news/news-897/)
Copper deficiency. Zincとの関連.

(https://ocu-radiology.jp/news/news-891/)
Takayasu’s arteritis. Atypical immunoblastic reaction that was consistent with primary Epstein–Barr virus infection.

(https://ocu-radiology.jp/news/news-783/)
NEJMの紹介、Case Recordsの変遷についての私見