＜論文紹介：NEJM 2021;384:166-176.他＞

NEJMがとても役立ちますよ、ということを以前お話ししましたが、
最新号から論文を紹介します。

「Case 1-2021: A 76-Year-Old Woman with Lethargy and Altered Mental Status.（NEJM 2021;384:166-176.）」
相変わらず重要ですね。放射線画像も臨床経過も教育的です。
Table 2の鑑別表がおすすめです。

ついでに、最近のNEJM論文も紹介します。

「BRIEF REPORT. Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants. （NEJM 2021;384:42-50.）」
新生児は出産直後に泣くことで呼吸を開始する際に羊水を吸い込む。出産直後に 母体の子宮頸癌細胞が混じった羊水を肺に吸い込むことによって、新生児に経気 道的に肺転移が生じたという症例。

「ORIGINAL ARTICLE. Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.（NEJM 2020;383:1878-1884）」
ユビキチン関連遺伝子変異によるVEXAS(vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic)症候群という成人発症自己炎症症候群のお話。

「Case 40-2020: A 24-Year-Old Man with Headache and Covid-19.（NEJM 2020;383:2572-2580.）」
教育的症例ですが、画像が解説通りに見えるかどうか私には微妙です。

 

他のNEJM関連は、こちら。
（かなり数がたまったので今後はリンクははりません。ご了承ください。
内容を記載しますので、ご関心があればリンク先アドレスをコピペしてご参照く ださい。）

（https://ocu-radiology.jp/news/news-3082/）
Primary hyperparathyroidism due to an ectopic parathyroid carcinoma.
Necrotizing granulomatous lymphadenitis due to Mycobacterium tuberculosis complex.
Tuberculous pericarditis.
Aceruloplasminemia, hereditary.
Sensory Ganglionopathy.
Borrelia miyamotoi infection.
Autophagy in Human Diseas

（https://ocu-radiology.jp/news/news-3050/）
Disseminated cryptococcosis.
Cryptococcus neoformans.
Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.
boric acid toxicity.
Human immunodeficiency virus type 2 infection and cerebral toxoplasmosis.
New-Onset Diabetes in Covid-19.

（https://ocu-radiology.jp/news/news-3023/）
Pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Lead poisoning.
Acute Ischemic Stroke.
Degenerative Cervical Spondylosis.

（https://ocu-radiology.jp/news/news-2980/）
Whipple’s disease.
Variant Creutzfeldt–Jakob Disease.
Down Syndrome.
Phosphaturic mesenchymal tumor.
LGI1 autoimmune encephalitis.

（https://ocu-radiology.jp/news/news-2903/）
Fascioliasis (Eosinophilia).
Proteinase 3 antineutrophil cytoplasmic antibody–associated vasculitis consistent with granulomatosis with polyangiitis.
Hantavirus cardiopulmonary syndrome.
PSA Screening.

（https://ocu-radiology.jp/news/news-2788/）
Intraparenchymal and intracranial hemorrhage presumably due to birth trauma.
小児虐待.
Pulmonary tumor thrombotic microangiopathy

（https://ocu-radiology.jp/news/news-2758/）
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Treatment for Spontaneous Pneumothorax.
Fatal Cytomegalovirus Infection with Inherited NOS2 Deficiency.
Strongyloidiasis with human T-lymphotropic virus type 1 infection.
Disseminated coccidioidomycosis and ANCA-associated glomerulonephritis.
Photopheresis for Colitis Induced by Checkpoint-Inhibitor Therapy.
Machine Learning and the Cancer-Diagnosis Problem.
Diffuse pulmonary alveolar hemorrhage with focal infarction with vaping.

（https://ocu-radiology.jp/news/news-2601/）：
Identification of Anonymous MRI Research Participants with Face-Recognition Software.
Cerebellar form of Creutzfeldt–Jakob disease.
Adenovirus meningoencephalitis.
Imaging of Vaping-Associated Lung Disease.

（https://ocu-radiology.jp/news/news-2550/）：
Interstitial lung disease associated with FLNA mutation.
Spondyloarthritis in patients with inflammatory bowel disease (Crohn’s disease).
Inhaled GM-CSF for Pulmonary Alveolar Proteinosis.

（https://ocu-radiology.jp/news/news-2464/）：
Pregnant woman with Acute suppurative appendicitis and periappendicitis.
Pheochromocytoma and Paraganglioma.
Drug-Induced Liver Injury.
New Guidelines for Statistical Reporting in the Journal.

（https://ocu-radiology.jp/news/news-2436/）：
Leber’s hereditary optic neuropathy.
Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis.
Intestinal tuberculosis.

（https://ocu-radiology.jp/news/news-2403/）：
Anaplastic carcinoma arising in association with intestinal-type mucinous carcinoma of the ovary.
（いわゆる　Mucinous cystic tumours with mural nodules）
West Nile virus encephalitis/West Nile virus meningoencephalitis.

（https://ocu-radiology.jp/news/news-2371）：
Systemic lupus erythematosus.
Contrast-Associated Acute Kidney Injury.
Mesenchymal Hamartoma of the Liver and DICER1 Syndrome.
Metastatic postpubertal immature teratoma.
Machine Learning in Medicine.

（https://ocu-radiology.jp/news/news-2148/）：
Idiopathic pulmonary fibrosis.
Pulmonary alveolar proteinosis.
Mucinous Ovarian Carcinoma.
Ocular syphilis.

（https://ocu-radiology.jp/news/news-2115/）：
Herpes simplex virus lymphadenitis, Chronic lymphocytic leukemia.
Perforation of the sigmoid colon by a foreign body (toothpick) that caused a fistula to the right common iliac artery.
Powassan virus encephalitis.

（https://ocu-radiology.jp/news/news-2037/）：
Papulonecrotic tuberculid (cutaneous tuberculosis).
Hepatobiliary Tuberculosis.
Sudden death caused by pulmonary fat embolism in a patient with miliary tuberculosis.

（https://ocu-radiology.jp/news/news-1974/）：
眼窩領域Granulomatosis with polyangiitis, Susac’s syndrome.
Clostridium perfringens bacteremia with a hepatic abscess.
Osteoblastic and Osteolytic Spine Metastases by Using SWI.

（https://ocu-radiology.jp/news/news-1921/）：
The t(6;11) TFEB translocation variant of renal-cell carcinoma.
比較的新しい病理組織概念でUncommonな腎腫瘤の復習.

（https://ocu-radiology.jp/news/news-1901/）：
Pulmonary adenocarcinoma, hypercoagulable state with nonbacterial thrombotic endocarditis.
BK Virus–Progressive Multifocal Leukoencephalopathy.

（https://ocu-radiology.jp/news/news-1843/）：
Anti–N-methyl-d-aspartate (NMDA) receptor encephalitis.
The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, associated with human herpesvirus 6.
Acute Viral Encephalitis. 特にarbovirus encephalitisについて.

（https://ocu-radiology.jp/news/news-1793/）：
Vitamin C deficiency (scurvy).“bachelor scurvy”
Vitamin B6, folate, zinc, and selenium deficiencies.
Alcohol-use disorder.
Multiple vitamin deficiencies.

（https://ocu-radiology.jp/news/news-1681/）：
Polyarteritis nodosa. HBVとの関連.

（https://ocu-radiology.jp/news/news-1605/）：
Membranous nephropathy, PLA2R type. IgG4との関連性など.
Idiopathic Pulmonary Fibrosis.

（https://ocu-radiology.jp/news/news-1588/）：
Giant-cell myocarditis.
Takotsubo cardiomyopathy and catecholamine-induced crisis due to pheochromocytoma.
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.

（https://ocu-radiology.jp/news/news-1462/）：
Homocystinuriaの様々な表現型：Cystathionine β-synthase deficiency, Methylenetetrahydrofolate reductase deficiency.
Primary Sjögren’s Syndrome.
Antibody-Mediated Encephalitis.

（https://ocu-radiology.jp/news/news-1374/）：
Immune-Related Adverse Events Associated with Immune Checkpoint Blockade.
Multiple Sclerosis. Neuromyelitis Optica Spectrum Disorders.
Adenovirus infection, disseminated.

（https://ocu-radiology.jp/news/news-1253/）：
Biotin–thiamine–responsive basal ganglia disease.

（https://ocu-radiology.jp/news/news-1109/）：
好酸球増多症（Eosinophilia）について.

（https://ocu-radiology.jp/news/news-897/）：
Copper deficiency. Zincとの関連.

（https://ocu-radiology.jp/news/news-891/）：
Takayasu’s arteritis.
Atypical immunoblastic reaction that was consistent with primary Epstein–Barr virus infection.

（https://ocu-radiology.jp/news/news-783/）：
NEJMの紹介、Case Recordsの変遷についての私見.