＜論文紹介：NEJM 2022;386:1742-1749. 他＞

1223

NEJMがとても役立ちますよ、ということを以前お話ししましたが、最近のNEJM論文を紹介します。

「CLINICAL PROBLEM-SOLVING: Looking Back.（NEJM 2022;386:1742-1749.）」
本病態は、臨床上とても大切で、様々なところに発生します。

「Case 15-2022: A 57-Year-Old Man with Persistent Cough and Pulmonary Opacities.（NEJM 2022;386:1933-1944.）」
こんなによく出会う病態なのに、難しい！

「Case 16-2022: A 55-Year-Old Man with Fevers, Night Sweats, and a Mediastinal Mass.（NEJM 2022;386:2036-2048.）」
この病態もすっかりお馴染みになっていますね。

 

他のNEJM関連は、こちら。
（かなり数がたまったので今後はリンクははりません。ご了承ください。
内容を記載しますので、ご関心があればリンク先アドレスをコピペしてご参照ください。）

(https://ocu-radiology.jp/news/news-3734/)
Constrictive bronchiolitis due to military service. Cryptogenic Organizing Pneumonia. Hereditary angioedema type I due to heterozygous deletion of exons 5 and 6 in SERPING1

（https://ocu-radiology.jp/news/news-3654/）
Multistate Outbreak of Melioidosis Associated with Imported Aromatherapy Spray. Fever of Unknown Origin.  post–Covid-19 Hemophagocytic lymphohistiocytosis (HLH).

（https://ocu-radiology.jp/news/news-3608/）
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. Anti-IgLON5 IgG–associated neurologic disorder. HHV-6 encephalitis associated with CD19-directed CAR-T therapy.

（https://ocu-radiology.jp/news/news-3589/）
Fat embolism syndrome.  Anti–melanoma differentiation–associated protein 5 (anti–MDA-5) dermatomyositis. Legionella pneumonia. Spontaneous Intracranial Hypotension.

（https://ocu-radiology.jp/news/news-3561/）
Pneumocystis jirovecii pneumonia. Seizure from neurocysticercosis. Primary hyperparathyroidism and brown tumor. Vascular Ehlers–Danlos syndrome.

（https://ocu-radiology.jp/news/news-3513/）
Systemic juvenile idiopathic arthritis. Challenges of Sarcoidosis and Its Management. Chronic Meningitis. Acute human immunodeficiency virus type 1 infection.

（https://ocu-radiology.jp/news/news-3490/）
Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS) due to a biallelic expansion in RFC1. Delayed posthypoxic leukoencephalopathy. Vasculopathy and myocardial infarction associated with Neurofibromatosis type 1. Nodular follicular thyroid neoplasm with a somatic NRAS mutation.

（https://ocu-radiology.jp/news/news-3354/）
Adrenal Incidentaloma. Bartonella henselae infection (cat scratch disease). Suprasellar CNS germinoma. Extrahepatic Manifestations of Chronic HCV Infection. Leptospirosis.

（https://ocu-radiology.jp/news/news-3212/）
Lymphoplasmacytic lymphoma of the central nervous system (Bing–Neel syndrome).  Disseminated Mycobacterium bovis infection.  Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. Systemic primary amyloidosis.

（https://ocu-radiology.jp/news/news-3133/）
Mycobacterium tuberculosis meningitis. Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants. Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease. Cryptococcal meningoencephalitis and advanced human immunodeficiency virus infection.

（https://ocu-radiology.jp/news/news-3082/）
Primary hyperparathyroidism due to an ectopic parathyroid carcinoma. Necrotizing granulomatous lymphadenitis due to Mycobacterium tuberculosis complex. Tuberculous pericarditis. Aceruloplasminemia, hereditary. Sensory Ganglionopathy. Borrelia miyamotoi infection. Autophagy in Human Diseas

（https://ocu-radiology.jp/news/news-3050/）
Disseminated cryptococcosis. Cryptococcus neoformans. Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency. boric acid toxicity. Human immunodeficiency virus type 2 infection and cerebral toxoplasmosis. New-Onset Diabetes in Covid-19.

（https://ocu-radiology.jp/news/news-3023/）
Pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Lead poisoning. Acute Ischemic Stroke. Degenerative Cervical Spondylosis.

（https://ocu-radiology.jp/news/news-2980/）
Whipple’s disease. Variant Creutzfeldt–Jakob Disease. Down Syndrome. Phosphaturic mesenchymal tumor. LGI1 autoimmune encephalitis.

（https://ocu-radiology.jp/news/news-2903/）
Fascioliasis (Eosinophilia). Proteinase 3 antineutrophil cytoplasmic antibody–associated vasculitis consistent with granulomatosis with polyangiitis. Hantavirus cardiopulmonary syndrome. PSA Screening.

（https://ocu-radiology.jp/news/news-2788/）
Intraparenchymal and intracranial hemorrhage presumably due to birth trauma. 小児虐待. Pulmonary tumor thrombotic microangiopathy

（https://ocu-radiology.jp/news/news-2758/）
A Novel Coronavirus from Patients with Pneumonia in China, 2019. Treatment for Spontaneous Pneumothorax. Fatal Cytomegalovirus Infection with Inherited NOS2 Deficiency. Strongyloidiasis with human T-lymphotropic virus type 1 infection. Disseminated coccidioidomycosis and ANCA-associated glomerulonephritis. Photopheresis for Colitis Induced by Checkpoint-Inhibitor Therapy. Machine Learning and the Cancer-Diagnosis Problem. Diffuse pulmonary alveolar hemorrhage with focal infarction with vaping.

（https://ocu-radiology.jp/news/news-2601/）
Identification of Anonymous MRI Research Participants with Face-Recognition Software. Cerebellar form of Creutzfeldt–Jakob disease. Adenovirus meningoencephalitis. Imaging of Vaping-Associated Lung Disease.

（https://ocu-radiology.jp/news/news-2550/）
Interstitial lung disease associated with FLNA mutation. Spondyloarthritis in patients with inflammatory bowel disease (Crohn’s disease). Inhaled GM-CSF for Pulmonary Alveolar Proteinosis.

（https://ocu-radiology.jp/news/news-2464/）
Pregnant woman with Acute suppurative appendicitis and periappendicitis. Pheochromocytoma and Paraganglioma. Drug-Induced Liver Injury. New Guidelines for Statistical Reporting in the Journal.

（https://ocu-radiology.jp/news/news-2436/）
Leber’s hereditary optic neuropathy. Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis. Intestinal tuberculosis.

（https://ocu-radiology.jp/news/news-2403/）
Anaplastic carcinoma arising in association with intestinal-type mucinous carcinoma of the ovary. （いわゆるMucinous cystic tumours with mural nodules） West Nile virus encephalitis/West Nile virus meningoencephalitis.

（https://ocu-radiology.jp/news/news-2371）
Systemic lupus erythematosus. Contrast-Associated Acute Kidney Injury. Mesenchymal Hamartoma of the Liver and DICER1 Syndrome. Metastatic postpubertal immature teratoma. Machine Learning in Medicine.

（https://ocu-radiology.jp/news/news-2148/）
Idiopathic pulmonary fibrosis. Pulmonary alveolar proteinosis. Mucinous Ovarian Carcinoma. Ocular syphilis.

（https://ocu-radiology.jp/news/news-2115/）
Herpes simplex virus lymphadenitis, Chronic lymphocytic leukemia. Perforation of the sigmoid colon by a foreign body (toothpick) that caused a fistula to the right common iliac artery. Powassan virus encephalitis.

（https://ocu-radiology.jp/news/news-2037/）
Papulonecrotic tuberculid (cutaneous tuberculosis). Hepatobiliary Tuberculosis. Sudden death caused by pulmonary fat embolism in a patient with miliary tuberculosis.

（https://ocu-radiology.jp/news/news-1974/）
眼窩領域Granulomatosis with polyangiitis, Susac’s syndrome. Clostridium perfringens bacteremia with a hepatic abscess. Osteoblastic and Osteolytic Spine Metastases by Using SWI.

（https://ocu-radiology.jp/news/news-1921/）
The t(6;11) TFEB translocation variant of renal-cell carcinoma. 比較的新しい病理組織概念でUncommonな腎腫瘤の復習.

（https://ocu-radiology.jp/news/news-1901/）
Pulmonary adenocarcinoma, hypercoagulable state with nonbacterial thrombotic endocarditis. BK Virus–Progressive Multifocal Leukoencephalopathy.

（https://ocu-radiology.jp/news/news-1843/）
Anti–N-methyl-d-aspartate (NMDA) receptor encephalitis. The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, associated with human herpesvirus 6. Acute Viral Encephalitis. 特にarbovirus encephalitisについて.

（https://ocu-radiology.jp/news/news-1793/）
Vitamin C deficiency (scurvy).“bachelor scurvy” Vitamin B6, folate, zinc, and selenium deficiencies. Alcohol-use disorder. Multiple vitamin deficiencies.

（https://ocu-radiology.jp/news/news-1681/）
Polyarteritis nodosa. HBVとの関連.

（https://ocu-radiology.jp/news/news-1605/）
Membranous nephropathy, PLA2R type. IgG4との関連性など. Idiopathic Pulmonary Fibrosis.

（https://ocu-radiology.jp/news/news-1588/）
Giant-cell myocarditis. Takotsubo cardiomyopathy and catecholamine-induced crisis due to pheochromocytoma. Fulminant Myocarditis with Combination Immune Checkpoint Blockade.

（https://ocu-radiology.jp/news/news-1462/）
Homocystinuriaの様々な表現型：Cystathionine β-synthase deficiency, Methylenetetrahydrofolate reductase deficiency. Primary Sjögren’s Syndrome. Antibody-Mediated Encephalitis.

（https://ocu-radiology.jp/news/news-1374/）
Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. Multiple Sclerosis. Neuromyelitis Optica Spectrum Disorders. Adenovirus infection, disseminated.

（https://ocu-radiology.jp/news/news-1253/）
Biotin–thiamine–responsive basal ganglia disease.

（https://ocu-radiology.jp/news/news-1109/）
好酸球増多症（Eosinophilia）について.

（https://ocu-radiology.jp/news/news-897/）
Copper deficiency. Zincとの関連.

（https://ocu-radiology.jp/news/news-891/）
Takayasu’s arteritis. Atypical immunoblastic reaction that was consistent with primary Epstein–Barr virus infection.

（https://ocu-radiology.jp/news/news-783/）
NEJMの紹介、Case Recordsの変遷についての私見.