＜論文紹介：NEJM 2022;386:274-283.他＞

NEJMがとても役立ちますよ、ということを以前お話ししましたが、最近のNEJM論文を紹介します。

「Case 2-2022: A 70-Year-Old Man with a Recurrent Left Pleural Effusion.（NEJM 2022;386:274-283.）」
ついに出てきました！
今後、報告例が増えそうな重要な疾患です。

「Case 1-2022: A 67-Year-Old Man with Motor Neuron Disease and Odd Behaviors during Sleep.（NEJM 2022;386:173-180.）」
これもついに出てきました！
今後、やはり報告例が増えそうな重要な疾患です。

「CLINICAL PROBLEM-SOLVING: Confused about Confusion.（NEJM 2022;386:80-87）」
CAR-T療法下では、いろんな事が起こります。
要注意ですね。

他のNEJM関連は、こちら。
（かなり数がたまったので今後はリンクははりません。ご了承ください。
内容を記載しますので、ご関心があればリンク先アドレスをコピペしてご参照ください。）

（https://ocu-radiology.jp/news/news-3589/）
Fat embolism syndrome.
Anti–melanoma differentiation–associated protein 5 (anti–MDA-5) dermatomyositis.
Legionella pneumonia.
Spontaneous Intracranial Hypotension.

（https://ocu-radiology.jp/news/news-3561/）
Pneumocystis jirovecii pneumonia.
Seizure from neurocysticercosis.
Primary hyperparathyroidism and brown tumor.
Vascular Ehlers–Danlos syndrome.

（https://ocu-radiology.jp/news/news-3513/）
Systemic juvenile idiopathic arthritis.
Challenges of Sarcoidosis and Its Management.
Chronic Meningitis.
Acute human immunodeficiency virus type 1 infection.

（https://ocu-radiology.jp/news/news-3490/）
Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS) due to a biallelic expansion in RFC1.
Delayed posthypoxic leukoencephalopathy.
Vasculopathy and myocardial infarction associated with Neurofibromatosis type 1.
Nodular follicular thyroid neoplasm with a somatic NRAS mutation.

（https://ocu-radiology.jp/news/news-3354/）
Adrenal Incidentaloma.
Bartonella henselae infection (cat scratch disease).
Suprasellar CNS germinoma.
Extrahepatic Manifestations of Chronic HCV Infection.
Leptospirosis.

（https://ocu-radiology.jp/news/news-3212/）
Lymphoplasmacytic lymphoma of the central nervous system (Bing–Neel syndrome).
Disseminated Mycobacterium bovis infection.
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia.
Systemic primary amyloidosis.

（https://ocu-radiology.jp/news/news-3133/）
Mycobacterium tuberculosis meningitis.
Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants.
Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.
Cryptococcal meningoencephalitis and advanced human immunodeficiency virus infection.

（https://ocu-radiology.jp/news/news-3082/）
Primary hyperparathyroidism due to an ectopic parathyroid carcinoma.
Necrotizing granulomatous lymphadenitis due to Mycobacterium tuberculosis complex.
Tuberculous pericarditis.
Aceruloplasminemia, hereditary.
Sensory Ganglionopathy.
Borrelia miyamotoi infection.
Autophagy in Human Diseas

（https://ocu-radiology.jp/news/news-3050/）
Disseminated cryptococcosis.
Cryptococcus neoformans.
Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.
boric acid toxicity.
Human immunodeficiency virus type 2 infection and cerebral toxoplasmosis.
New-Onset Diabetes in Covid-19.

（https://ocu-radiology.jp/news/news-3023/）
Pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Lead poisoning.
Acute Ischemic Stroke.
Degenerative Cervical Spondylosis.

（https://ocu-radiology.jp/news/news-2980/）
Whipple’s disease.
Variant Creutzfeldt–Jakob Disease.
Down Syndrome.
Phosphaturic mesenchymal tumor.
LGI1 autoimmune encephalitis.

（https://ocu-radiology.jp/news/news-2903/）
Fascioliasis (Eosinophilia).
Proteinase 3 antineutrophil cytoplasmic antibody–associated vasculitis consistent with granulomatosis with polyangiitis.
Hantavirus cardiopulmonary syndrome.
PSA Screening.

（https://ocu-radiology.jp/news/news-2788/）
Intraparenchymal and intracranial hemorrhage presumably due to birth trauma.
小児虐待.
Pulmonary tumor thrombotic microangiopathy

（https://ocu-radiology.jp/news/news-2758/）
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Treatment for Spontaneous Pneumothorax.
Fatal Cytomegalovirus Infection with Inherited NOS2 Deficiency.
Strongyloidiasis with human T-lymphotropic virus type 1 infection.
Disseminated coccidioidomycosis and ANCA-associated glomerulonephritis.
Photopheresis for Colitis Induced by Checkpoint-Inhibitor Therapy.
Machine Learning and the Cancer-Diagnosis Problem.
Diffuse pulmonary alveolar hemorrhage with focal infarction with vaping.

（https://ocu-radiology.jp/news/news-2601/）：
Identification of Anonymous MRI Research Participants with Face-Recognition Software.
Cerebellar form of Creutzfeldt–Jakob disease.
Adenovirus meningoencephalitis.
Imaging of Vaping-Associated Lung Disease.

（https://ocu-radiology.jp/news/news-2550/）：
Interstitial lung disease associated with FLNA mutation.
Spondyloarthritis in patients with inflammatory bowel disease (Crohn’s disease).
Inhaled GM-CSF for Pulmonary Alveolar Proteinosis.

（https://ocu-radiology.jp/news/news-2464/）：
Pregnant woman with Acute suppurative appendicitis and periappendicitis.
Pheochromocytoma and Paraganglioma.
Drug-Induced Liver Injury.
New Guidelines for Statistical Reporting in the Journal.

（https://ocu-radiology.jp/news/news-2436/）：
Leber’s hereditary optic neuropathy.
Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis.
Intestinal tuberculosis.

（https://ocu-radiology.jp/news/news-2403/）：
Anaplastic carcinoma arising in association with intestinal-type mucinous carcinoma of the ovary.
（いわゆる　Mucinous cystic tumours with mural nodules）
West Nile virus encephalitis/West Nile virus meningoencephalitis.

（https://ocu-radiology.jp/news/news-2371）：
Systemic lupus erythematosus.
Contrast-Associated Acute Kidney Injury.
Mesenchymal Hamartoma of the Liver and DICER1 Syndrome.
Metastatic postpubertal immature teratoma.
Machine Learning in Medicine.

（https://ocu-radiology.jp/news/news-2148/）：
Idiopathic pulmonary fibrosis.
Pulmonary alveolar proteinosis.
Mucinous Ovarian Carcinoma.
Ocular syphilis.

（https://ocu-radiology.jp/news/news-2115/）：
Herpes simplex virus lymphadenitis, Chronic lymphocytic leukemia.
Perforation of the sigmoid colon by a foreign body (toothpick) that caused a fistula to the right common iliac artery.
Powassan virus encephalitis.

（https://ocu-radiology.jp/news/news-2037/）：
Papulonecrotic tuberculid (cutaneous tuberculosis).
Hepatobiliary Tuberculosis.
Sudden death caused by pulmonary fat embolism in a patient with miliary tuberculosis.

（https://ocu-radiology.jp/news/news-1974/）：
眼窩領域Granulomatosis with polyangiitis, Susac’s syndrome.
Clostridium perfringens bacteremia with a hepatic abscess.
Osteoblastic and Osteolytic Spine Metastases by Using SWI.

（https://ocu-radiology.jp/news/news-1921/）：
The t(6;11) TFEB translocation variant of renal-cell carcinoma.
比較的新しい病理組織概念でUncommonな腎腫瘤の復習.

（https://ocu-radiology.jp/news/news-1901/）：
Pulmonary adenocarcinoma, hypercoagulable state with nonbacterial thrombotic endocarditis.
BK Virus–Progressive Multifocal Leukoencephalopathy.

（https://ocu-radiology.jp/news/news-1843/）：
Anti–N-methyl-d-aspartate (NMDA) receptor encephalitis.
The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, associated with human herpesvirus 6.
Acute Viral Encephalitis. 特にarbovirus encephalitisについて.

（https://ocu-radiology.jp/news/news-1793/）：
Vitamin C deficiency (scurvy).“bachelor scurvy”
Vitamin B6, folate, zinc, and selenium deficiencies.
Alcohol-use disorder.
Multiple vitamin deficiencies.

（https://ocu-radiology.jp/news/news-1681/）：
Polyarteritis nodosa. HBVとの関連.

（https://ocu-radiology.jp/news/news-1605/）：
Membranous nephropathy, PLA2R type. IgG4との関連性など.
Idiopathic Pulmonary Fibrosis.

（https://ocu-radiology.jp/news/news-1588/）：
Giant-cell myocarditis.
Takotsubo cardiomyopathy and catecholamine-induced crisis due to pheochromocytoma.
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.

（https://ocu-radiology.jp/news/news-1462/）：
Homocystinuriaの様々な表現型：Cystathionine β-synthase deficiency, Methylenetetrahydrofolate reductase deficiency.
Primary Sjögren’s Syndrome.
Antibody-Mediated Encephalitis.

（https://ocu-radiology.jp/news/news-1374/）：
Immune-Related Adverse Events Associated with Immune Checkpoint Blockade.
Multiple Sclerosis. Neuromyelitis Optica Spectrum Disorders.
Adenovirus infection, disseminated.

（https://ocu-radiology.jp/news/news-1253/）：
Biotin–thiamine–responsive basal ganglia disease.

（https://ocu-radiology.jp/news/news-1109/）：
好酸球増多症（Eosinophilia）について.

（https://ocu-radiology.jp/news/news-897/）：
Copper deficiency. Zincとの関連.

（https://ocu-radiology.jp/news/news-891/）：
Takayasu’s arteritis.
Atypical immunoblastic reaction that was consistent with primary Epstein–Barr virus infection.

（https://ocu-radiology.jp/news/news-783/）：
NEJMの紹介、Case Recordsの変遷についての私見.