<論文紹介:NEJM 2024;390:1105-1117.ほか>


ORIGINAL ARTICLE: Anti–Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency.(NEJM 2024;390:1105-1117.)
Among patients with a variety of mycobacterial, bacterial, or fungal infections, the presence of neutralizing anti–interleukin-23 was associated with severe, persistent opportunistic infections.


CORRESPONDENCE: Kidney Injury and Hair-Straightening Products Containing Glyoxylic Acid.(NEJM 2024;390:1147-1149.)


Case 7-2024: A 67-Year-Old Woman with Alternating Sixth Cranial Nerve Palsy.(NEJM 2024;390:843-851.)


REVIEW ARTICLE: Behçet’s Syndrome.(NEJM 2024;390:640-651.)




Coccidioidomycosis  and Histoplasmosis in Immunocompetent Persons.
Keratinizing desquamative squamous metaplasia due to vitamin A deficiency occurred after a bariatric operation.
Syphilis Complicating Pregnancy and Congenital Syphilis.


Hereditary angioedema. Cronkhite–Canada syndrome.
Methemoglobinemia Outbreak in a Neonatal ICU and Maternity Ward.
Eye Infections.

Chorea due to antiphospholipid syndrome and underlying systemic lupus erythematosus.
Schnitzler’s syndrome.
HNF1B-related disease consistent with renal cysts and diabetes spectrum disorder.
Liver Transplantation in a Woman with Mahvash Disease.

Granulomatous lung disease as an extraintestinal manifestation of inflammatory bowel disease.
Primary pericardial mesothelioma without pleural involvement.
Carcinoid heart disease due to a metastatic well-differentiated neuroendocrine tumor (carcinoid tumor) associated with carcinoid

Noncirrhotic hyperammonemia after Roux-en-Y gastric bypass.
Periengraftment respiratory distress syndrome, a subtype of idiopathic pneumonia syndrome.
Current and Emerging Issues in Wilson’s Disease.

Protein-Losing Enteropathy.
Juvenile granulosa-cell tumor.
Multiple vitamin deficiencies, including vitamin C deficiency.
Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
RAS-associated autoimmune leukoproliferative disorder.
Congenital absence of the main portal vein with a congenital
extrahepatic portosystemic shunt (Abernethy malformation).

Systemic immunoglobulin light-chain (AL) amyloidosis.
Sarcoidosis associated with tattoos.
Mansonella perstans infection.

Cystic fibrosis
Functional vitamin B12 deficiency from use of nitrous oxide.
The Current and Future State of AI Interpretation of Medical

Arterial calcification due to deficiency of CD73.
Systemic lupus erythematosus with membranous lupus nephritis.
A hepatic brucelloma.

Paraneoplastic vasculitis of the central nervous system.
Primary biliary cholangitis with portopulmonary hypertension.
Catastrophic antiphospholipid syndrome.

Hepatic adenoma, inflammatory type, with associated ischemic
necrosis and extensive hemorrhage.
Cardiac paraganglioma with a germline mutation in the gene
encoding succinate dehydrogenase subunit C (SDHC).
Primary Ovarian Insufficiency.
Cushing’s syndrome due to ectopic secretion of adrenocorticotropic
hormone from small-cell lung cancer.

Adrenocortical carcinoma.
Disseminated Mycobacterium tuberculosis infection.
Whipple’s disease.
Optic nerve sheath meningioma.


IgA vasculitis.
Granulomatosis with polyangiitis.
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked
(IPEX) syndrome.
Neonatal hypoglycemia due to biologically active teratoma and
the Sotos syndrome.


Langerhans-cell histiocytosis of the lung and liver.
Chronic Candida albicans meningitis.
Bronchiectasis — A Clinical Review.
Exogenous lipoid pneumonia with a supportive history of mineral
oil ingestion.


Takayasu’s arteritis.
Granulomatosis with polyangiitis.
Infection with Blastomyces dermatitidis.

Spinal gout.
Aspiration pneumonia.
Idiopathic multicentric Castleman’ s disease (TAFRO subtype).

Constrictive bronchiolitis due to military service. Cryptogenic
Organizing Pneumonia. Hereditary angioedema type I due to
deletion of exons 5 and 6 in SERPING1

Multistate Outbreak of Melioidosis Associated with Imported
Aromatherapy Spray.
Fever of Unknown Origin.
post–Covid-19 Hemophagocytic lymphohistiocytosis (HLH).

VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic)
Anti-IgLON5 IgG–associated neurologic disorder. HHV-6 encephalitis
associated with CD19-directed CAR-T therapy.

Fat embolism syndrome. Anti–melanoma differentiation–associated
protein 5 (anti–MDA-5) dermatomyositis. Legionella pneumonia.
Spontaneous Intracranial Hypotension.

Pneumocystis jirovecii pneumonia. Seizure from neurocysticercosis.
Primary hyperparathyroidism and brown tumor.
Vascular  Ehlers–Danlos syndrome.

Systemic juvenile idiopathic arthritis. Challenges of Sarcoidosis and Its Management.
Chronic Meningitis. Acute human immunodeficiency virus type 1 infection.

Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS) due to a biallelic expansion in RFC1.
Delayed posthypoxic leukoencephalopathy.
Vasculopathy and myocardial infarction associated with Neurofibromatosis type 1.
Nodular follicular thyroid neoplasm with a somatic NRAS

Adrenal Incidentaloma. Bartonella henselae infection (cat scratch disease).
Suprasellar CNS germinoma. Extrahepatic Manifestations of Chronic HCV Infection. Leptospirosis.

Lymphoplasmacytic lymphoma of the central nervous system(Bing–Neel syndrome).
Disseminated Mycobacterium bovis infection.
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. Systemic primary amyloidosis.

Mycobacterium tuberculosis meningitis. Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants.
Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.
Cryptococcal meningoencephalitis and advanced human
immunodeficiency virus infection.

Primary hyperparathyroidism due to an ectopic parathyroid carcinoma.
Necrotizing granulomatous lymphadenitis due to Mycobacterium tuberculosis complex.
Tuberculous pericarditis.
Aceruloplasminemia, hereditary. Sensory Ganglionopathy. Borrelia miyamotoi infection. Autophagy in Human Diseas

Disseminated cryptococcosis. Cryptococcus neoformans. Congenital
Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency. boric acid
Human immunodeficiency virus type 2 infection and cerebral
toxoplasmosis. New-Onset Diabetes in Covid-19.

Pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Lead poisoning.
Acute Ischemic Stroke. Degenerative Cervical Spondylosis.

Whipple’s disease. Variant Creutzfeldt–Jakob Disease. Down Syndrome.
Phosphaturic mesenchymal tumor. LGI1 autoimmune encephalitis.


Fascioliasis (Eosinophilia). Proteinase 3 antineutrophil
cytoplasmic antibody–associated vasculitis consistent with
granulomatosis with polyangiitis. Hantavirus cardiopulmonary
syndrome. PSA Screening.

Intraparenchymal and intracranial hemorrhage presumably due to birth trauma.
小児虐待. Pulmonary tumor thrombotic microangiopathy

A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Treatment for Spontaneous Pneumothorax. Fatal Cytomegalovirus Infection with Inherited NOS2 Deficiency.
Strongyloidiasis with human T-lymphotropic virus type 1 infection.
Disseminated coccidioidomycosis and ANCA-associated glomerulonephritis.
Photopheresis for Colitis Induced by Checkpoint-Inhibitor Therapy.
Machine Learning and the Cancer-Diagnosis Problem.
Diffuse pulmonary alveolar hemorrhage with focal infarction with vaping.

Identification of Anonymous MRI Research Participants with Face-Recognition Software.
Cerebellar form of Creutzfeldt–Jakob disease.
Adenovirus meningoencephalitis. Imaging of Vaping-Associated Lung Disease.

Interstitial lung disease associated with FLNA mutation. Spondyloarthritis in patients with inflammatory bowel disease (Crohn’s disease).
Inhaled GM-CSF for Pulmonary Alveolar Proteinosis.

Pregnant woman with Acute suppurative appendicitis and periappendicitis.
Pheochromocytoma and Paraganglioma. Drug-Induced Liver Injury.
New Guidelines for Statistical Reporting in the Journal.

Leber’s hereditary optic neuropathy. Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis.
Intestinal tuberculosis.

Anaplastic carcinoma arising in association with intestinal-type mucinous carcinoma of the ovary.
(いわゆるMucinous cystic tumours with mural nodules)
West Nile virus encephalitis/West Nile virus meningoencephalitis.

Systemic lupus erythematosus. Contrast-Associated Acute Kidney Injury.
Mesenchymal Hamartoma of the Liver and DICER1 Syndrome.
Metastatic postpubertal immature teratoma. Machine Learning in Medicine.

Idiopathic pulmonary fibrosis. Pulmonary alveolar proteinosis.
Mucinous Ovarian Carcinoma. Ocular syphilis.

Herpes simplex virus lymphadenitis, Chronic lymphocytic leukemia.
Perforation of the sigmoid colon by a foreign body (toothpick) that caused a fistula to the right common iliac artery. Powassan virus encephalitis.

Papulonecrotic tuberculid (cutaneous tuberculosis).
Hepatobiliary Tuberculosis. Sudden death caused by pulmonary fat embolism in a patient with miliary tuberculosis.

眼窩領域Granulomatosis with polyangiitis, Susac’s syndrome.
Clostridium perfringens bacteremia with a hepatic abscess.
Osteoblastic and Osteolytic Spine Metastases by Using SWI.

The t(6;11) TFEB translocation variant of renal-cell carcinoma.

Pulmonary adenocarcinoma, hypercoagulable state with nonbacterial thrombotic endocarditis.
BK Virus–Progressive Multifocal Leukoencephalopathy.

Anti–N-methyl-d-aspartate (NMDA) receptor encephalitis.
The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, associated with human herpesvirus 6. Acute Viral Encephalitis.
特にarbovirus encephalitisについて.

Vitamin C deficiency (scurvy).“bachelor scurvy” Vitamin B6, folate, zinc, and selenium deficiencies.
Alcohol-use disorder. Multiple vitamin deficiencies.

Polyarteritis nodosa. HBVとの関連.

Membranous nephropathy, PLA2R type. IgG4との関連性など. Idiopathic Pulmonary Fibrosis.

Giant-cell myocarditis. Takotsubo cardiomyopathy and catecholamine-induced crisis due to pheochromocytoma.
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.

Homocystinuriaの様々な表現型:Cystathionine β-synthase deficiency, Methylenetetrahydrofolate reductase deficiency.
Primary Sjögren’s Syndrome. Antibody-Mediated Encephalitis.

Immune-Related Adverse Events Associated with Immune Checkpoint Blockade.
Multiple Sclerosis. Neuromyelitis Optica Spectrum Disorders.
Adenovirus infection, disseminated.

Biotin–thiamine–responsive basal ganglia disease.


Copper deficiency. Zincとの関連.

Takayasu’s arteritis. Atypical immunoblastic reaction that was consistent with primary Epstein–Barr virus infection.

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