NEJMがとても役立ちますよ、ということを以前お話ししましたが、最近のNEJM論文を紹介します。
「CORRESPONDENCE: Pegivirus-Associated Encephalomyelitis in Immunosuppressed Patients.（NEJM 2025;392:1864-1866.）」
フラビウイルス科ペギウイルス属に属するヒトペギウイルス1型（HPgV-1）による新たな中枢神経感染症が紹介されています。
「CLINICAL PRACTICE: Cancer of Unknown Primary Site.（NEJM 2025;392:2035-2047.）」
原発不明癌に関する総説です。
「Case 15-2025: A 52-Year-Old Man with Fever, Nausea, and Respiratory Failure.（NEJM 2025;392:2049-2057.）」
日本ではなかなかお目にかかれない病態です。
他のNEJM関連は、こちら。
（かなり数がたまったので今後はリンクははりません。ご了承ください。内容を記載しますので、ご関心があればリンク先アドレスをコピペしてご参照ください。）
（https://ocu-radiology.jp/news/news-5581/）
Phospholipase A2 receptor–associated membranous nephropathy. DSP mutation linked to arrhythmogenic cardiomyopathy. Malaria. Powassan virus encephalitis.
（https://ocu-radiology.jp/news/news-5450/）
Hemophagocytic Lymphohistiocytosis. Acquired Osteomalacia Associated with Autoantibodies against PHEX. Sarcoidosis (Löfgren’s syndrome). AL amyloidosis.
（https://ocu-radiology.jp/news/news-5429/）
childhood-onset SLE. Disseminated Mycobacterium kansasii and Mycobacterium abscessus infections due to mendelian susceptibility to mycobacterial disease. Intralobar bronchopulmonary sequestration.
（https://ocu-radiology.jp/news/news-5140/）
Brain abscess due to infection with Listeria monocytogenes. Secondary Syphilis with Osteitis. Icteric leptospirosis. Rosai– Dorfman–Destombes disease.
（https://ocu-radiology.jp/news/news-5083/）
Primary Central Nervous System Vasculitis. Pancreatic Cysts. A New Orthonairovirus Associated with Human Febrile Illness. Nutritional optic neuropathy due to multiple nutritional deficits, including vitamin A, copper, and zinc deficiencies.
（https://ocu-radiology.jp/news/news-5052/）
Paraneoplastic encephalomyelitis due to small-cell lung carcinoma and concurrent cerebral amyloid angiopathy. Sweet’s syndrome. Common variable immunodeficiency. Congenital and Acquired Chiari Syndrome.
（https://ocu-radiology.jp/news/news-4953/）
Reversible cerebral vasoconstriction syndrome with takotsubo cardiomyopathy. T-Cell Cancer after CAR T-Cell Therapy. Highly Pathogenic Avian Influenza A(H5N1) Virus Infection in a Dairy Farm Worker. MIDD (maternally inherited diabetes and deafness) and MELAS (mitochondrial encephalopathy, lactic acidosis, and strokelike episodes) associated with the m.3243A→G pathogenic variant.
（https://ocu-radiology.jp/news/news-4726/）
Anti–Interleukin-23 Autoantibodies in Adult-Onset Immunodeficiency. Kidney Injury and Hair-Straightening Products Containing Glyoxylic Acid. Myeloperoxidase antineutrophil cytoplasmic antibody–associated vasculitis. Behçet’s Syndrome.
（https://ocu-radiology.jp/news/news-4624/）
Coccidioidomycosis and Histoplasmosis in Immunocompetent Persons.Keratinizing desquamative squamous metaplasia due to vitamin A deficiency occurred after a bariatric operation.
Syphilis Complicating Pregnancy and Congenital Syphilis.
（https://ocu-radiology.jp/2024/01/04/post-4597/）
Hereditary angioedema. Cronkhite–Canada syndrome. Methemoglobinemia Outbreak in a Neonatal ICU and Maternity Ward. Eye Infections.
（https://ocu-radiology.jp/news/news-4583/）
Chorea due to antiphospholipid syndrome and underlying systemic lupus erythematosus. Schnitzler’s syndrome. HNF1B-related disease consistent with renal cysts and diabetes spectrum disorder. Liver Transplantation in a Woman with Mahvash Disease.
（https://ocu-radiology.jp/news/news-4552/）
Granulomatous lung disease as an extraintestinal manifestation of inflammatory bowel disease. Primary pericardial mesothelioma without pleural involvement. Carcinoid heart disease due to a metastatic well-differentiated neuroendocrine tumor (carcinoid tumor) associated with carcinoid syndrome.
（https://ocu-radiology.jp/news/news-4460/）
Noncirrhotic hyperammonemia after Roux-en-Y gastric bypass. Periengraftment respiratory distress syndrome, a subtype of idiopathic pneumonia syndrome. Current and Emerging Issues in Wilson’s Disease.
（https://ocu-radiology.jp/news/news-4383/）
Protein-Losing Enteropathy. Juvenile granulosa-cell tumor. Multiple vitamin deficiencies, including vitamin C deficiency. Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency. Histoplasmosis. RAS-associated autoimmune leukoproliferative disorder. Congenital absence of the main portal vein with a congenital extrahepatic portosystemic shunt (Abernethy malformation).
（https://ocu-radiology.jp/news/news-4306/）
Systemic immunoglobulin light-chain (AL) amyloidosis. Sarcoidosis associated with tattoos. Mansonella perstans infection.
（https://ocu-radiology.jp/news/news-4250/）
Cystic fibrosis Functional vitamin B12 deficiency from use of nitrous oxide. The Current and Future State of AI Interpretation of Medical Images.
（https://ocu-radiology.jp/news/news-4177/）
Arterial calcification due to deficiency of CD73. Systemic lupus erythematosus with membranous lupus nephritis. A hepatic brucelloma.
（https://ocu-radiology.jp/news/news-4096/）
Paraneoplastic vasculitis of the central nervous system. Primary biliary cholangitis with portopulmonary hypertension. Catastrophic antiphospholipid syndrome.
（https://ocu-radiology.jp/news/news-4062/）
Hepatic adenoma, inflammatory type, with associated ischemic necrosis and extensive hemorrhage. Cardiac paraganglioma with a germline mutation in the gene encoding succinate dehydrogenase subunit C (SDHC). Primary Ovarian Insufficiency. Cushing’s syndrome due to ectopic secretion of adrenocorticotropic hormone from small-cell lung cancer.
（https://ocu-radiology.jp/news/news-4035/）
Adrenocortical carcinoma. Disseminated Mycobacterium tuberculosis infection. Whipple’s disease. Optic nerve sheath meningioma. Sarcoidosis.
（https://ocu-radiology.jp/news/news-3897/）
IgA vasculitis. Granulomatosis with polyangiitis. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Neonatal hypoglycemia due to biologically active teratoma and the Sotos syndrome.
（https://ocu-radiology.jp/news/news-3897/）
Langerhans-cell histiocytosis of the lung and liver. Chronic Candida albicans meningitis. Bronchiectasis — A Clinical Review. Exogenous lipoid pneumonia with a supportive history of mineral oil ingestion.
（https://ocu-radiology.jp/news/news-3861/）
Takayasu’s arteritis. Granulomatosis with polyangiitis. Infection with Blastomyces dermatitidis.
（https://ocu-radiology.jp/news/news-3787/）
Spinal gout. Aspiration pneumonia. Idiopathic multicentric Castleman’ s disease (TAFRO subtype).
（https://ocu-radiology.jp/news/news-3734/)
Constrictive bronchiolitis due to military service. Cryptogenic Organizing Pneumonia. Hereditary angioedema type I due to heterozygous deletion of exons 5 and 6 in SERPING1.
（https://ocu-radiology.jp/news/news-3654/）
Multistate Outbreak of Melioidosis Associated with Imported Aromatherapy Spray. Fever of Unknown Origin. post–Covid-19 Hemophagocytic lymphohistiocytosis (HLH).
（https://ocu-radiology.jp/news/news-3608/）
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome. Anti-IgLON5 IgG–associated neurologic disorder. HHV-6 encephalitis associated with CD19-directed CAR-T therapy.
（https://ocu-radiology.jp/news/news-3589/）
Fat embolism syndrome. Anti–melanoma differentiation–associated protein 5 (anti–MDA-5) dermatomyositis. Legionella pneumonia. Spontaneous Intracranial Hypotension.
（https://ocu-radiology.jp/news/news-3561/）
Pneumocystis jirovecii pneumonia. Seizure from neurocysticercosis. Primary hyperparathyroidism and brown tumor. Vascular Ehlers–Danlos syndrome.
（https://ocu-radiology.jp/news/news-3513/）
Systemic juvenile idiopathic arthritis. Challenges of Sarcoidosis and Its Management. Chronic Meningitis. Acute human immunodeficiency virus type 1 infection.
（https://ocu-radiology.jp/news/news-3490/）
Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS) due to a biallelic expansion in RFC1. Delayed posthypoxic leukoencephalopathy. Vasculopathy and myocardial infarction associated with Neurofibromatosis type 1. Nodular follicular thyroid neoplasm with a somatic NRAS mutation.
（https://ocu-radiology.jp/news/news-3354/）
Adrenal Incidentaloma. Bartonella henselae infection (cat scratch disease). Suprasellar CNS germinoma. Extrahepatic Manifestations of Chronic HCV Infection. Leptospirosis.
（https://ocu-radiology.jp/news/news-3212/）
Lymphoplasmacytic lymphoma of the central nervous system(Bing–Neel syndrome). Disseminated Mycobacterium bovis infection. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. Systemic primary amyloidosis.
（https://ocu-radiology.jp/news/news-3133/）
Mycobacterium tuberculosis meningitis. Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants. Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease. Cryptococcal meningoencephalitis and advanced human immunodeficiency virus infection.
（https://ocu-radiology.jp/news/news-3082/）
Primary hyperparathyroidism due to an ectopic parathyroid carcinoma. Necrotizing granulomatous lymphadenitis due to Mycobacterium tuberculosis complex. Tuberculous pericarditis. Aceruloplasminemia, hereditary. Sensory Ganglionopathy. Borrelia miyamotoi infection. Autophagy in Human Diseas.
（https://ocu-radiology.jp/news/news-3050/）
Disseminated cryptococcosis. Cryptococcus neoformans. Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency. boric acid toxicity. Human immunodeficiency virus type 2 infection and cerebral toxoplasmosis. New-Onset Diabetes in Covid-19.
（https://ocu-radiology.jp/news/news-3023/）
Pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Lead poisoning. Acute Ischemic Stroke. Degenerative Cervical Spondylosis.
（https://ocu-radiology.jp/news/news-2980/）
Whipple’s disease. Variant Creutzfeldt–Jakob Disease. Down Syndrome. Phosphaturic mesenchymal tumor. LGI1 autoimmune encephalitis.
（https://ocu-radiology.jp/news/news-2903/）
Fascioliasis (Eosinophilia). Proteinase 3 antineutrophil cytoplasmic antibody–associated vasculitis consistent with granulomatosis with polyangiitis. Hantavirus cardiopulmonary
syndrome. PSA Screening.
（https://ocu-radiology.jp/news/news-2788/）
Intraparenchymal and intracranial hemorrhage presumably due to
birth trauma.
小児虐待. Pulmonary tumor thrombotic microangiopathy.
（https://ocu-radiology.jp/news/news-2758/）
A Novel Coronavirus from Patients with Pneumonia in China, 2019. Treatment for Spontaneous Pneumothorax. Fatal Cytomegalovirus Infection with Inherited NOS2 Deficiency. Strongyloidiasis with human T-lymphotropic virus type 1 infection. Disseminated coccidioidomycosis and ANCA-associated glomerulonephritis. Photopheresis for Colitis Induced by Checkpoint-Inhibitor Therapy. Machine Learning and the Cancer-Diagnosis Problem. Diffuse pulmonary alveolar hemorrhage with focal infarction with vaping.
（https://ocu-radiology.jp/news/news-2601/）
Identification of Anonymous MRI Research Participants with Face-Recognition Software. Cerebellar form of Creutzfeldt–Jakob disease. Adenovirus meningoencephalitis. Imaging of Vaping-Associated Lung Disease.
（https://ocu-radiology.jp/news/news-2550/）
Interstitial lung disease associated with FLNA mutation. Spondyloarthritis in patients with inflammatory bowel disease (Crohn’s disease). Inhaled GM-CSF for Pulmonary Alveolar Proteinosis.
（https://ocu-radiology.jp/news/news-2464/）
Pregnant woman with Acute suppurative appendicitis and periappendicitis. Pheochromocytoma and Paraganglioma. Drug-Induced Liver Injury. New Guidelines for Statistical Reporting in the Journal.
（https://ocu-radiology.jp/news/news-2436/）
Leber’s hereditary optic neuropathy. Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis. Intestinal tuberculosis.
（https://ocu-radiology.jp/news/news-2403/）
Anaplastic carcinoma arising in association with intestinal-type mucinous carcinoma of the ovary.
（いわゆるMucinous cystic tumours with mural nodules）West Nile virus encephalitis/West Nile virus meningoencephalitis.
（https://ocu-radiology.jp/news/news-2371）
Systemic lupus erythematosus. Contrast-Associated Acute Kidney Injury. Mesenchymal Hamartoma of the Liver and DICER1 Syndrome. Metastatic postpubertal immature teratoma. Machine Learning in Medicine.
（https://ocu-radiology.jp/news/news-2148/）
Idiopathic pulmonary fibrosis. Pulmonary alveolar proteinosis. Mucinous Ovarian Carcinoma. Ocular syphilis.
（https://ocu-radiology.jp/news/news-2115/）
Herpes simplex virus lymphadenitis, Chronic lymphocytic leukemia. Perforation of the sigmoid colon by a foreign body (toothpick) that caused a fistula to the right common iliac artery. Powassan virus encephalitis.
（https://ocu-radiology.jp/news/news-2037/）
Papulonecrotic tuberculid (cutaneous tuberculosis). Hepatobiliary Tuberculosis. Sudden death caused by pulmonary fat embolism in a patient with miliary tuberculosis.
（https://ocu-radiology.jp/news/news-1974/）
眼窩領域Granulomatosis with polyangiitis, Susac’s syndrome. Clostridium perfringens bacteremia with a hepatic abscess. Osteoblastic and Osteolytic Spine Metastases by Using SWI.
（https://ocu-radiology.jp/news/news-1921/）
The t(6;11) TFEB translocation variant of renal-cell carcinoma. 比較的新しい病理組織概念でUncommonな腎腫瘤の復習.
（https://ocu-radiology.jp/news/news-1901/）
Pulmonary adenocarcinoma, hypercoagulable state with nonbacterial thrombotic endocarditis. BK Virus–Progressive Multifocal Leukoencephalopathy.
（https://ocu-radiology.jp/news/news-1843/）
Anti–N-methyl-d-aspartate (NMDA) receptor encephalitis. The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, associated with human herpesvirus 6. Acute Viral Encephalitis.
特にarbovirus encephalitisについて.
（https://ocu-radiology.jp/news/news-1793/）
Vitamin C deficiency (scurvy).“bachelor scurvy” Vitamin B6, folate, zinc, and selenium deficiencies. Alcohol-use disorder. Multiple vitamin deficiencies.
（https://ocu-radiology.jp/news/news-1681/）
Polyarteritis nodosa. HBVとの関連.
（https://ocu-radiology.jp/news/news-1605/）
Membranous nephropathy, PLA2R type. IgG4との関連性など. Idiopathic Pulmonary Fibrosis.
（https://ocu-radiology.jp/news/news-1588/）
Giant-cell myocarditis. Takotsubo cardiomyopathy and catecholamine-induced crisis due to pheochromocytoma. Fulminant Myocarditis with Combination Immune Checkpoint Blockade.
（https://ocu-radiology.jp/news/news-1462/）
Homocystinuriaの様々な表現型：Cystathionine β-synthase deficiency, Methylenetetrahydrofolate reductase deficiency. Primary Sjögren’s Syndrome. Antibody-Mediated Encephalitis.
（https://ocu-radiology.jp/news/news-1374/）
Immune-Related Adverse Events Associated with Immune Checkpoint Blockade. Multiple Sclerosis. Neuromyelitis Optica Spectrum Disorders. Adenovirus infection, disseminated.
（https://ocu-radiology.jp/news/news-1253/）
Biotin–thiamine–responsive basal ganglia disease.
（https://ocu-radiology.jp/news/news-1109/）
好酸球増多症（Eosinophilia）について.
（https://ocu-radiology.jp/news/news-897/）
Copper deficiency. Zincとの関連.
（https://ocu-radiology.jp/news/news-891/）
Takayasu’s arteritis. Atypical immunoblastic reaction that was consistent with primary Epstein–Barr virus infection.
（https://ocu-radiology.jp/news/news-783/）
NEJMの紹介、Case Recordsの変遷についての私見